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The role of Sesn2/AMPK/mTOR signaling pathway in the abnormal glucose metabolism caused by intermittent hypoxia and reoxygenation
EP36153
Poster Title: The role of Sesn2/AMPK/mTOR signaling pathway in the abnormal glucose metabolism caused by intermittent hypoxia and reoxygenation
Submitted on 14 May 2021
Author(s): Xinjie Chen1,Hongfei Liu1,Jiahui Tian1,Huanhuan Jin1,Ruiting Ma1,Yan Liu1,Jing Du1,Lijue Ren1,Yunhui Lu2,Cuiying Wei1
Affiliations: 1.the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology. 2.Yunnan Provincial People's Hospital
This poster was presented at  The 3rd Congress of Asia Society of Sleep Medicine (ASSM 2021)
Poster Views: 113
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Poster Information
Abstract: Objectives
The effects of intermittent hypoxia-reoxygenation on fasting blood glucose (FBG) and fasting insulin (FINS) in rats, and explore the possible role of Sesn2/AMPK/mTOR signaling pathway.
Methods
36 rats were randomly divided into a control group (NC) and an experimental group, each with 18 rats. The experimental group was placed in an intermittent hypoxic chamber for 8 hours/d for 8 weeks, and then fed under normoxia for 4 weeks; The NC group was always fed under normoxia. The levels of FBG, FINS, liver Sesn2, AMPK, p-AMPK protein, mTOR and LC3mRNA in two groups were measured at baseline, at the 8th weekend and at the 12th weekend.
Results
Compared between groups, there was no statistically significant difference in various indicators at baseline (P>0.05); after 8 weeks of intermittent hypoxia, the levels of FBG, FINS, HOMA-IR, and mTOR in the experimental group increased, while Sesn2, p-AMPK/AMPK as well as the level of LC3 decreased, and the difference was statistically significant (P<0.05); after 4 weeks of reoxygenation, the standard indicators of the experimental group returned to the baseline level, and there was no statistically significant difference compared with the control group (P<0.05); Pearson correlation analysis showed that HOMA-IR was negatively correlated with Sesn2, p-AMPK/AMPK, and LC3 levels (r=-0.871, -0.974, -837, -0.828, P<0.05), but positively correlated with mTOR levels (r=0.851, P <0.05).
Conclusions
Chronic intermittent hypoxia can increase the levels of FBG and FINS in rats, which may induce down-regulation of autophagy by inhibiting the Sesn2/AMPK/mTOR signaling pathway in the liver, thereby mediating abnormal glucose metabolism.

Summary: Chronic intermittent hypoxia can increase the levels of FBG and FINS in rats, which may induce down-regulation of autophagy by inhibiting the Sesn2/AMPK/mTOR signaling pathway in the liver, thereby mediating abnormal glucose metabolism.Report abuse »
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