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EP38458
Poster Title: TIMS Viz for Mobility Offset Mass Aligned interrogation of complex samples
Submitted on 09 Mar 2022
Author(s): Philipp Strohmidel1, Sebastian Wehner1, Jens Decker1, Ignacio Jauregui1, Christopher Adams2, Tharan Srikumar2, Sven Brehmer1
Affiliations: 1Bruker Daltonics GmbH & Co. KG, Bremen, Germany 2Bruker, Inc., San Jose, CA, USA
Poster Views: 234
Submitted on 09 Mar 2022
Author(s): Philipp Strohmidel1, Sebastian Wehner1, Jens Decker1, Ignacio Jauregui1, Christopher Adams2, Tharan Srikumar2, Sven Brehmer1
Affiliations: 1Bruker Daltonics GmbH & Co. KG, Bremen, Germany 2Bruker, Inc., San Jose, CA, USA
Poster Views: 234
Abstract: • The PASEF acquisition mode of the timsTOF Pro 2 has the power to separate and isolate co-eluting, quasi-isobaric peptides for fragmentation
• The separation of quasi-isobaric peptides is based on differences in their ion mobility
• Such events are called Mobility Offset Mass Aligned (MOMA)
• MOMA events result in non-chimeric spectra, despite the quadrupoles fidelity not being sufficient to separate MOMA peptides by their m/z
• This can especially be valuable in PTM analysis, e.g. to resolve positional isomers in phosphoproteomics
Summary: The PASEF acquisition mode of the timsTOF Pro 2 has the power to separate and isolate co-eluting, quasi-isobaric peptides for fragmentation
• The separation of quasi-isobaric peptides is based on differences in their ion mobility
• Such events are called Mobility Offset Mass Aligned (MOMA)
• MOMA events result in non-chimeric spectra, despite the quadrupoles fidelity not being sufficient to separate MOMA peptides by their m/z
• This can especially be valuable in PTM analysis, e.g. to resolve positional isomers in phosphoproteomics
Summary: The PASEF acquisition mode of the timsTOF Pro 2 has the power to separate and isolate co-eluting, quasi-isobaric peptides for fragmentation
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