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Tolerance to Allergenic Foods Following Food Oral Immunotherapy (FOIT)
Poster Title: Tolerance to Allergenic Foods Following Food Oral Immunotherapy (FOIT)
Submitted on 09 Mar 2015
Author(s): AR Hague1, RL Wasserman1,2, SK Silvers1,2, RW Sugerman1,2, M Herbert3
Affiliations: 1Dallas Food Allergy Center/DallasAllergyImmunology, 2Medical City Children’s Hospital, 3Dept Clinical Research, Medical City Dallas Hospital
This poster was presented at American Academy of Allergy Asthma and Immunology Annual Meeting 2015
Poster Views: 1,920
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Poster Information
Abstract: Rationale: FOIT treatment desensitizes most food allergic individuals, but the achievement of immunologic tolerance is uncertain. We report on 21 selected patients who underwent food challenges (FC) after FOIT was withheld for at least 30 days.

Methods: Retrospective record review of FOIT patients approved by the North Texas IRB. After 453-1752 days of maintenance dosing selected patients stopped ingesting the allergenic food for 1 month and then were subjected to an open, graded FC.

Results: 19/21 patients passed the FC (FCP) (5/5 egg, 6/7 milk, 7/8 peanut, 1/1 cashew). 15/19 FCP and 0/2 who failed the FC (FCF) had a history of anaphylaxis to the allergenic food prior to starting FOIT. Median IgE (kU/L) before beginning FOIT for FCP were egg 5.04 (0.37-49.97), milk 5.23 (1.52-10.93), peanut 10.39 (2.44-61.33), cashew 4.53; and for FCF: milk 54.24, peanut >100. Median IgE values before FC for FCP were egg 0.35 (0.1-15.9), milk 0.17 (0.08-0.3), peanut 0.96 (0.08-7.38), and cashew 1.14; and milk 1.16, peanut 11.5 for FCF. There were 0.26 epinephrine treated reactions per patient (ETRpp) during FOIT escalation and 0.05 ETRpp during maintenance for FCP. There were 2 ETRs in escalation and none in maintenance for the 2 FCF patients.

Conclusions: 90% of selected FOIT patients achieved tolerance to their allergenic food. These data suggest that patients with high pre-OIT IgE values, high pre-FC values, and more ETRs during escalation are less likely to pass FC. More FOIT patients will need to undergo FC before meaningful conclusions may be drawn concerning tolerance.
Summary: We report on 21 patients who completed FOIT (food oral immunotherapy) escalation followed by a period of maintenance dosing and later underwent a tolerance FC (food challenge). 90% of tested FOIT patients and 94% of patients who met our pre-defined criteria for tolerance FC achieved tolerance to their allergenic food.
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6. Pence DM, Hague AR, Wasserman,RL, et,. al. JACI, 135:2, AB27. AAAAI. Houston, TX, February, 2015.
7. Gallucci-Hague AR, Wasserman RL, Sugerman RW, et. al. JACI, 127:2, AB25. AAAAI. San Francisco, CA, March 2011.
8. Hague AR, Wasserman RL, Sugerman RW. JACI, 129:2, AB29. AAAAI. Oralando, FL, March 2012.
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