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Translational Research of oral Neural Crest-Derived Stem Cells (oNCSCs) in Regenerative Dentistry
Poster Title: Translational Research of oral Neural Crest-Derived Stem Cells (oNCSCs) in Regenerative Dentistry
Submitted on 22 Oct 2015
Author(s): Grimm W.-D1,2,4, S. N. Alekseenko9, D. V. Bobryshev1, W. Duncan11, B. Giesenhagen3, E. Gubareva9, Sema S. Hakki6, O.V. Pershina7, I. Schau4, S. V. Sirak1, E.G. Skurikhin7, A. A. Sletov1, F. Witte10, G. Varga8, O. V. Vladimirova1, M.A. Vukovic2, D. Widera5
Affiliations: 1Stavropol State Medical University, Russian Federation, 2Praxisteam Hasslinghausen, Germany, 3Implantology Center Kassel, Germany, 4Witten/ Herdecke University, Germany, 5University of Reading, UK, 6Selcuk University, Konya, Turkey, 7Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation, 8Semmelweis University, Budapest, Hungary, 9Kuban State Medical University, Russian Federation, 10Center for Regenerative Therapies Charité - University Medicine Berlin, Germany, 11University of Otago, New Zealand
This poster was presented at World Conference on Regenerative Medicine, Leipzig 2015
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Poster Information
Abstract: Regeneration of periodontal tissues aims to utilize tissue engineering techniques to restore lost periodontal tissues including cementum, periodontal ligament and alveolar bone. Regenerative dentistry and its special field regenerative periodontology represent relatively new and emerging branches of translational stem cell biology and regenerative medicine focusing on replacing and regenerating dental tissues to restore or re-establish their normal function lost during degenerative diseases or acute lesions. The regeneration itself can be achieved through transplantation of autologous or allogeneic stem cells, or by improving the tissue self-repair mechanisms (e.g. by application of growth factors). In addition, a combination of stem cells or stem cell-containing tissue with bone implants can be used to improve tissue integration and the clinical outcome. As the oral cavity represents a complex system consisting of teeth, bone, soft tissues and sensory nerves, regenerative periodontology relies on the use of stem cells with relatively high developmental potential. Notably, the potential use of pluripotent stem cell types such as human embryonic stem cells or induced pluripotent stem cells is still hampered by ethical and practical problems. Thus, other cellular sources such as those readily available in the postnatal cranio-facial area and particularly in oral structures offer a much better and realistic alternative as cellular regenerative sources.Summary: In this review poster, we summarize current knowledge on the oral neural crest-derived stem cell populations (oNCSCs) and discuss their potential in regenerative periodontology as a part of regenerative dentistry.References: W.-D. Grimm1,2,3,4 & B. Giesenhagen5 & S. Hakki 6 & I. Schau1 & S. Sirak2 & A. Sletov2 &
G. Varga8 & M. A. Vukovic4 & D. Widera7
Translational Research and Therapeutic Applications of Neural Crest-Derived Stem Cells in Regenerative Periodontology
Curr Oral Health Rep
DOI 10.1007/s40496-015-0067-6
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