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Trends in Pattern of Disease in Penile Cancer: Concerns Raised by the National Cancer Data Base
EP27152
Poster Title: Trends in Pattern of Disease in Penile Cancer: Concerns Raised by the National Cancer Data Base
Submitted on 08 Feb 2018
Author(s): Sharon Chaing
Affiliations: University of South Florida
This poster was presented at USF Research Day 2018
Poster Views: 651
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Poster Information
Abstract: Introduction –
* Analyzed current trends in penile squamous cell carcinoma (SCC) in the United States.
* Determined socioeconomic predictors for locally-advanced 9pT3/T4) disease using National Cancer Data Base (NCDB).
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Method –
* Queried the NCDB, a large, nationwide cancer registry, for patients with clinically nonmetastic penile SCC and available pathologic staging between 1998 and 2012.
* Analyzed temporal trends in overall incidence and pathologic tumor stage.
* Used a multivariate logistic regression model to identify predictors for pT3/T4 presentation between 1998 to 2012.
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Results –
* Identified 4,316 patients:
** ≤ pT1/T2 (n= 3,886)
** pT3/T4 (n = 430)
* Increasing trends were found in all stages of penile SCC.
* Significant rise seen in the proportion of pT3/T4 cases (p < 0.001).
* Positive predictors for advanced disease were:
** age > 55 (OR = 1.63, 95%CI: 1.18 – 2.26; p = 0.003)
** year of diagnosis, stratified as 2008 – 2012 (OR = 1.54; 95% CI: 1.12 – 2.12; p = 0.008)
** lack of insurance (OR = 2.11; 95%CI: 1.36 – 3.27; p = 0.001).
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Conclusions –
* From 1998 to 2012, there has been an increased incidence of penile SCC and a significantly higher proportion of locally advanced tumors over time.
* Age, recent diagnosis (2008 – 2012), and insurance status were identified as positive predictors for advanced disease and thus may pose as potential barriers to standard care for penile cancer patients in the United states.
Summary: This study on current trends of penile SCC cases diagnosed between 1998 and 2012 in the US draws attention to a worrisome, significant rise in penile cancer in the U.S. with a concurrent higher proportion of locally-advanced disease presentation, especially in the last five years of the study period (2008 – 2012). Additionally, it highlights access to care/insurance as a major area for improvement in penile cancer.Report abuse »
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