Abstract: NGS has now be extensively applied to molecular mapping of tumor heterogeneity, tumor diagnosis and prognosis prediction in clinical settings, as well as new drug discoveries. Furthermore, there has been a remarkable acceleration in the use of NGS to develop individualized treatment. To support medical research and translation, we provide a full range of sequencing/microarray-based approaches including gene expression profiling, RNA-seq, whole-genome sequencing (WGS), whole exome sequencing (WES), epigenomics, and single-cell sequencing for detecting tumor heterogeneity.Summary: Tumors are marked by high levels of tumor heterogeneity, out-of-control cell growth, and metastasis. They encompass and competing ecosystem, including tumor-cell-related epithelial cells, fibroblasts, infiltrated immune cells, mesenchymal stem cells (MSCs), and surrounding endothelium of blood vessels. References:
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