Posters
« Back
Tutorials and Spreadsheets for Designing Valid Least Squares Calibrations
EP23566
Poster Title: Tutorials and Spreadsheets for Designing Valid Least Squares Calibrations
Submitted on 30 Oct 2015
Author(s): Ricardo J. N. Bettencourt da Silva
Affiliations: Centro de Química Estrutural (CQE-FCUL), University of Lisbon, PORTUGAL
This poster was presented at Pittcon 2015
Poster Views: 1,209
View poster »


Poster Information
Abstract: Many important decisions are based on results from instrumental methods of analysis such as the price of goods, the compliance of products with legal requirements or the outcome of research based on chemical analysis.
A measurement procedure can only play its role properly if the reported information is objective and has the required quality. The reporting of measurement with uncertainty makes information objective since it defines an interval that should encompass the expected value of the measured quantity with a known probability.
Different strategies for the evaluation of the measurement uncertainty can be used. The “bottom-up” approach involves dissecting the measurement procedure in individual uncertainty components responsible either for random or systematic effects, the quantification of these components and the determination of the combined effect of the various components. This approach is difficult to apply due to the complexity of involved models.
This work consists in the development of tutorials for the validation of quantifications performed by instrumental methods of analysis based on least-squares regressions. These tutorials include: 1) the definition of the Limit of Detection and calibration range, 2) the definition of the procedure for calibrators preparation, 3) the evaluation of the applicability of the regression model for describing the calibration curve and 4) the assessment of the measurement uncertainty using the “bottom-up” approach. The various stages are completed in a sequence of user-friendly MS-Excel spreadsheets. These tools were developed to be used by less experienced analysts and to ensure the production of sound metrological information.
Summary: This work consists in the development of tutorials for the validation of quantifications performed by instrumental methods of analysis based on least-squares regressions. The various stages are completed in a sequence of user-friendly MS-Excel spreadsheets.
Report abuse »
Questions
Ask the author a question about this poster.
Ask a Question »

Creative Commons

Related Posters


Resident: DKA: A Story of Access to Insulin
Erik Rodriguez, MD., Vaidehi Ambai, DO., Viktoria Nurpiesov, MD., G.E., Alan Dever, MD, PhD.

Resident: OPIOIDS: A Case Of Rhabdomyolysis Due To Alcohol And Opioid Abuse
Aileen Polanco, MD, Ibraheem Innab, MD, Paul Mathieu, MD, Samina Fakhr, MD, Victoria Nurpiesov, MD, G.E. Alan Dever, MD, PhD,

ANEURYSM ENCASED IN ANTERIOR SKULL BASE MENINGIOMA : REVIEW OF TWO CASES
Dr Raghavendra H

Resident: Neutropenic Fever with Acute Diarrheal Illness
Juilett Kostanjevec, D.O. PGY 2; Nida Jiwani, D.O. PGY 1; Daniel Frilingos, M.D.; Amimi Osayande, M.D., FAAFP.

Resident: Strickland Weight Loss Initiative
Syed Ahmed M.D. PGY3; Brandon Alyas M.D, PGY 3, Anant Patel D.O. PGY1; Pedro Ramirez M.D. PGY1