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EP22240
Poster Title: Use of transabdominal color doppler ultrasound for detection of colon cancer in patients with nonspecific abdominal symptoms:a personal experience and meta analysis of the literature
Submitted on 02 Oct 2014
Author(s): Nives Tarle Bajić, Iva Bajić
Affiliations: Croatian Society for Ultrasound in Medicine and Biology
This poster was presented at BIR Annual congress
Poster Views: 6,384
Submitted on 02 Oct 2014
Author(s): Nives Tarle Bajić, Iva Bajić
Affiliations: Croatian Society for Ultrasound in Medicine and Biology
This poster was presented at BIR Annual congress
Poster Views: 6,384
Abstract: Methods.The objective of this study was to demonstrate the place of TCDU (transabdominal color Doppler ultrasound) in the diagnosis of colon cancer and confirmation of colon cancer through colonoscopy. In this retrospective study, we presented 331 examined patients who underwent TCDU in 2009–2011.We examined 180 women and 151 men aged 40–86 years (mean±standard deviation [SD], (63±23) with nonspecific symptoms (distension and abdominal pain, abnormal stools, bowel disorders, iron deficiency anemia, and weakness).
Results.In 20.5% (68/331) of patients, focal lesions were detected in the colon through TCDU screening, while in 82.3% of these (56/68) or 16.9% (56/331) overall, bowel cancer was confirmed with colonoscopy. In this research, TCDU presented a sensitivity of 94.9%, specificity of 95.59%, a PPV of 82.35%, and an NPV of 98.86%. We presented a meta-analysis in which we have compared three independent studies, specifically Martinez et al. (2005), Chen et al. (2006), and our study. The results suggested significantly higher incidence of the colorectal cancer could be successfully found through ultrasound examination (Mantel-Haenszel, Robins-Breslow-Greenland) pooled odds ratio (OR)=204.9 (95% CI=106.4 to 394.5), Chi² (testing whether OR differs from 1)=717.4; p<0,001. From these results, we infer with 95% confidence, assuming a random effects model, that the true size of the difference between the OR for colon cancer was somewhere between 106.4 and 394.5.This was statistically significant at p <0.001.
Conclusion. The overall conclusion of this study is that in patients who have nonspecific symptoms in abdomen, TCDU should be the first choice to examine the abdomen.
Summary: The objective of this study was to demonstrate the place of TCDU in the diagnosis of colon cancer and confirmation of colon cancer through colonoscopyReferences: REFERENCES
1. Cappell M S. The patophysiology, clinical presentation, and diagnosis of colon canacer and adenomatous polyps. Med Clin N Am 2005 ;89:1-42.
2. Calderwood AH, Roy HK. Increasing colorectal canacer screening adherence. Comment on „Randomized comparison of print and web communication on colorectal canacer screening“.JAMA Intern Med. 2013;173(2):129-131.
3. Hoffmeister M, Brenner H. Seks–specific prevalence of adenomas and colorectal cancer. JAMA. 2013;307(2):142-147.
4. Loftus WK, Metreweli C, Sung JJY, Yang WT, Leung VKS, Set PAK. Ultrasound , CT and colonoscopy of colonic cancer. B J Radiol 1999;72:144-148.
5. Martinez Ares D, Martin-Granzio Barrenechea I, Souto-Ruzo J, Yanez Lopez J, Pallares Peral A, Vazquez-Iglesias JL. The value of abdominal ultrasound in the diagnosis of colon cancer. Rev Esp Enferm Dig 2005;97(12):877-886.
6. Roccarina D, Garcovich M, Ainora ME, et al. Diagnosis of bowel diseases:The role of imaging and ultrasonograph
Results.In 20.5% (68/331) of patients, focal lesions were detected in the colon through TCDU screening, while in 82.3% of these (56/68) or 16.9% (56/331) overall, bowel cancer was confirmed with colonoscopy. In this research, TCDU presented a sensitivity of 94.9%, specificity of 95.59%, a PPV of 82.35%, and an NPV of 98.86%. We presented a meta-analysis in which we have compared three independent studies, specifically Martinez et al. (2005), Chen et al. (2006), and our study. The results suggested significantly higher incidence of the colorectal cancer could be successfully found through ultrasound examination (Mantel-Haenszel, Robins-Breslow-Greenland) pooled odds ratio (OR)=204.9 (95% CI=106.4 to 394.5), Chi² (testing whether OR differs from 1)=717.4; p<0,001. From these results, we infer with 95% confidence, assuming a random effects model, that the true size of the difference between the OR for colon cancer was somewhere between 106.4 and 394.5.This was statistically significant at p <0.001.
Conclusion. The overall conclusion of this study is that in patients who have nonspecific symptoms in abdomen, TCDU should be the first choice to examine the abdomen.
Summary: The objective of this study was to demonstrate the place of TCDU in the diagnosis of colon cancer and confirmation of colon cancer through colonoscopyReferences: REFERENCES
1. Cappell M S. The patophysiology, clinical presentation, and diagnosis of colon canacer and adenomatous polyps. Med Clin N Am 2005 ;89:1-42.
2. Calderwood AH, Roy HK. Increasing colorectal canacer screening adherence. Comment on „Randomized comparison of print and web communication on colorectal canacer screening“.JAMA Intern Med. 2013;173(2):129-131.
3. Hoffmeister M, Brenner H. Seks–specific prevalence of adenomas and colorectal cancer. JAMA. 2013;307(2):142-147.
4. Loftus WK, Metreweli C, Sung JJY, Yang WT, Leung VKS, Set PAK. Ultrasound , CT and colonoscopy of colonic cancer. B J Radiol 1999;72:144-148.
5. Martinez Ares D, Martin-Granzio Barrenechea I, Souto-Ruzo J, Yanez Lopez J, Pallares Peral A, Vazquez-Iglesias JL. The value of abdominal ultrasound in the diagnosis of colon cancer. Rev Esp Enferm Dig 2005;97(12):877-886.
6. Roccarina D, Garcovich M, Ainora ME, et al. Diagnosis of bowel diseases:The role of imaging and ultrasonograph
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