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Vapor Modified Transformation of Gas Ions of Small Molecules from a Range of Proton Affinities in Tandem Differential Mobility Spectrometry: Control of Quantitative Response Using Water Vapor
EP25655
Poster Title: Vapor Modified Transformation of Gas Ions of Small Molecules from a Range of Proton Affinities in Tandem Differential Mobility Spectrometry: Control of Quantitative Response Using Water Vapor
Submitted on 31 Mar 2017
Author(s): Hossein Shokri, Gary A. Eiceman
Affiliations: New Mexico State University
This poster was presented at Pittcon 2017
Poster Views: 699
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Poster Information
Abstract: Response to 19 compounds from 5 chemical families was determined using tandem DMS with ions prepared at 0.2 ppm moisture in DMS 1 and transformed in 650 ppm moisture in DMS2. Compounds from a range of proton affinities (PA) exhibited response inverse to PA providing a chemical method to control selectivity of detection. Energies from ab initio computations of protonated monomers MH+(H2O)n and proton bound dimers M2H+ of these substances matched favorably with displacement of M by water. This demonstrates the incorporation of a chemical control into the nascent advances in concepts of multi-stage mobility at ambient pressure under development in our laboratorySummary: Water as a reagent between DMS1 and DMS2 provides a control of selectivity of response.
The apparent mechanism is water displacement of M from protonated monomer and proton bound dimers derived from a substance
Decreases in response for low proton affinities can be explained using ion Gibbs free energies.
Ion structure could be considerable in solvation level of MH+(H2O)n in middle stage.
References: 1) N. Krylova, E. Krylov, G. A. Eiceman, J. A. Stone Effect of Moisture on the Field Dependence of Mobility for Gas-Phase Ions of organophosphorous compounds at Atmospheric Pressure with Field Asymmetric Ion Mobility Spectrometry Phys. Chem. A 2003, 107, 3648-3654
2) M. R. Menlyadiev, J. A. Stone, G. A. Eiceman, Tandem differential mobility spectrometry with chemical modification of ions Int. J. Ion Mobil. Spec. 2012,15, 123-130
3) Marlen R. Menlyadiev and Gary A. Eiceman, Tandem Differential Mobility Spectrometry in Purified Air for High-Speed Selective Vapor Detection Anal. Chem. 2014, 86 (5), 2395–2402
4) Jan Sunner, Gordon Nicol, and Paul Kebarle, Factors Determining Relative Sensitivity of Analytes in Positive Mode Atmospheric Pressure Ionization Mass Spectrometry, Anal. Chem. 1988, 60, 1300-1307
5) Jan Sunner, Michael G. Ikonomou, and Paul Kebarle, Sensitivity Enhancements Obtained at High Temperatures in Atmospheric Pressure Ionization Mass Spectrometry, Anal. C
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