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VITVO: Mimicking In Vivo Complexity  By The Innovative 3D Model
Poster Title: VITVO: Mimicking In Vivo Complexity By The Innovative 3D Model
Submitted on 13 Jun 2019
Author(s): Olivia Candini1, Giulia Grisendi1, Elisabetta Manuela Foppiani1, Matteo Brogli1, Beatrice Aramini2, Valentina Masciale3, Carlotta Spano1, Tiziana Petrachi4, Elena Veronesi4, Pierfranco Conte5,6, Giorgio Mari1 & Massimo Dominici1,3
Affiliations: 1Rigenerand srl, Medolla, Modena; 2Division of Chest Surgery, 3Division of Oncology, Department of Medical and Surgical Sciences for Children & Adults, University-Hospital of Modena and Reggio Emilia, Modena, Italy; 4Technopole of Mirandola, Mirandola, Modena, Italy; 5 Medical Oncology 2, Veneto Institute of Oncology IOV Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padova, Italy; 6Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
This poster was presented at 3D-Culture, Organoids & Tox Screening Europe 2019
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Poster Information
Abstract: 3D tumor cultures are a promising tool for in vitro rebuilding the in vivo behavior of cancer cells, for the development and validation of anti-tumor therapies. Various 3D cell culture technologies have been created to better represent in vivo biology. However, advantages and limitations exist. Therefore, we developed a novel 3D culture system named VITVO. VITVO is a flat, handheld and versatile 3D cell culture bioreactor that can be loaded with tumor and/or normal cells in combination to rapidly recreate in vitro an in vivo-like environment which can be monitored using a variety of read-outs. Herein, the use of VITVO in several assays focusing on oncology is reported and the efficacy of chemotherapy, biologics, and cell-based anti-cancer agents was tested by comparing VITVO with an in vivo preclinical xenotransplant model. The novel features offered by this platform within the different approaches suggest the potential of VITVO as an innovative 3D in vitro model for pre-clinical testing with a possible relevant application beside oncology field. VITVO may contributes to fill the gap between in silico hypothesis/in vitro results and in vivo settings, also significantly impacting on the 3D rules.
Summary: A flat, handheld and versatile 3D cell culture bioreactor was presented here. This platform, called VITVO, represents an innovative 3D in vitro model for pre-clinical investigations in drug testing, gene therapy, and immuno-oncology.References: 1.Shin, C. S., Kwak, B., Han, B. & Park, K. Development of an in Vitro 3D Tumor Model to Study Therapeutic Efficiency of an Anticancer Drug. Mol. Pharm. 10, 2167–2175 (2013).
2.Fischbach, C. et al. Engineering tumors with 3D scaffolds. Nat. Methods 4, 855–860 (2007).
3.Horning, J. L. et al. 3-D Tumor Model for In Vitro Evaluation of Anticancer Drugs. Mol. Pharm. 5, 849–862 (2008).
4.Candini O. et al. A Novel 3D In Vitro Platform for Pre-Clinical Investigations in Drug Testing, Gene Therapy, and Immuno-oncology Sci. Rep. 9:7154 (2019)
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