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Web Server For DDI Reliability
EP27164
Poster Title: Web Server For DDI Reliability
Submitted on 02 Aug 2018
Author(s): Dekai Rohlsen, Feng Cheng
Affiliations: University of South Florida
This poster was presented at USF Health Research Day 2018
Poster Views: 322
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Poster Information
Abstract: Identifying drug-drug interaction (DDI) is an important topic for the development of safe Pharmaceutical drugs and for the optimization of multidrug regimens for complex diseases. Poly-pharmacy increases the risk of DDIs. A pharmacokinetic interaction may occur if one drug affects the absorption, distribution, metabolism, or excretion (ADME) of another drug when two drugs given together. In this project, we construct a web server for predicting and showing possible pharmacokinetic DDIs between two drugs. We also introduced a reliability score to evaluate the probability of these DDIs. Our web server has the potential to help users better understand the mechanism of a pharmacokinetic DDI.
Summary: We have construct a web server for predicting and showing possible pharmacokinetic DDIs between two drugs. The user can access our database through GitHub website using R program.
Our web server has the potential to help users better understand the mechanism of a pharmacokinetic DDI. We also introduced a reliability score to quantitatively evaluate the probability of these DDIs.
References: 1. Grattagliano, I., Portincasa, P., D'Ambrosio, G., Palmieri, V.O., and Palasciano, G. Avoiding drug interactions: here's help. J Fam Pract. 2010; 59: 322–329
2. Percha B, Altman RB. Informatics confronts drug—drug interactions. Trends in pharmacological sciences. 2013. doi: 10.1016/j.tips.2013.11.005
3. Youden WJ. Cancer. Vol. 3. 1950. Index for rating diagnostic tests; pp. 32–35.
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