Posters

Latest ADME Tox Posters


Passive topical administration of nucleic acids to targeted skin cells via sub-50 nm capsules
Passive topical administration of nucleic acids to targeted skin cells via sub-50 nm capsules
G Unger1, V Korman1, D Tobolt1, M Fuentes de Abin2, R Kaspar3, B Kren2, J Ballantyne4, M Murtaugh2
1GeneSegues, Inc., Chaska, MN; 2University of Minnesota, Mpls., MN; 3Transderm, Inc., Santa Cruz, CA; 4Aldevron, Fargo, ND

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Subcutaneous Delivery of Diagnostics and RNAi to Primary and Metastatic Tumors via Actively-targeted sub-50 nm (s50) Capsules
Subcutaneous Delivery of Diagnostics and RNAi to Primary and Metastatic Tumors via Actively-targeted sub-50 nm (s50) Capsules
Vicci L. Korman1, Lucas Nacusi1, Alex J. Pretti1, Diane L. Tobolt1, J. David Robertson2, Gretchen M. Unger1
1GeneSegues Therapeutics, Eden Prairie, MN 55347; 2University of Missouri, Columbia, MO 65211

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Human iPSC-derived cardiomyocytes: A translational model to predict drug-induced cardiac arrhythmias and long-term toxicity
Human iPSC-derived cardiomyocytes: A translational model to predict drug-induced cardiac arrhythmias and long-term toxicity
R Kettenhofen1, G Luerman1, R Bucerius1, I Kopljar2, DJ Gallacher2, A De Bondt2, E Vlaminckx2, I Van Den Wyngaert2, HR Lu2, H Bohlen1
1 Axiogenesis AG, Cologne, Germany; 2 Discovery Sciences, Janssen Research and Development, Janssen Pharmaceutica, Beerse, Belgium Conference Contact: roman.bucerius@axiogenesis.com

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Electrophysiological and cardiotoxicological characterization of human iPSC-derived cardiomyocytes (hiPSC-CMs) in 3D microtissues and 2D monolayers
Electrophysiological and cardiotoxicological characterization of human iPSC-derived cardiomyocytes (hiPSC-CMs) in 3D microtissues and 2D monolayers
Hortigon-Vinagre, Maria P. 1,2 ; Zamora, Victor1,2 ; Mamta Chabria3 ; Liudmila Polonchuk3 ; Bucerius, Roman4; Burton, Francis. L.1,2 ; Smith, Godfrey L.1,2
1. Clyde Biosciences, Ltd., Biocity Scotland, Bo’Ness Rd., ML1 5UH Newhouse (UK) 2. Institute of Cardiovascular and Medical Sciences, University of Glasgow, G12 8QQ, Glasgow (UK) 3. Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070, Basel, Switzerland 4. Axiogenesis AG, Cologne, Germany

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Multiwell optogenetics for enhanced control of human iPSC-derived cells
Multiwell optogenetics for enhanced control of human iPSC-derived cells
IP Clements, DC Millard, AM Nicolini, CA Arrowood, SA Chvatal, M Clements, JD Ross
Axion BioSystems

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CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluation
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluation
DC Millard, AM Nicolini, SA Chvatal, HB Hayes, M Clements, JD Ross
Axion BioSystems

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THE REASON BEHIND THE OPTIMAL FAILURE OF MEDICATION IN ICU AT THE END STAGE OF CHF
THE REASON BEHIND THE OPTIMAL FAILURE OF MEDICATION IN ICU AT THE END STAGE OF CHF
P. Mukesh raja, K. Rose mary, Sk. Rihana parveen, K. Venkata ramana

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Improvement of Human iPS Cell-Derived Hepatocyte Functionality Using 3D Culture System
Improvement of Human iPS Cell-Derived Hepatocyte Functionality Using 3D Culture System
Lin ZYC; Tamura K; Akahira R; Annand RR; Yoshida S; Hayashi Y
ReproCELL, Yohakama, Japan and Lexington, MA, USA

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An Oasis in the Desert: Sourcing Corals From Harbors for Reef Restoration
An Oasis in the Desert: Sourcing Corals From Harbors for Reef Restoration
L. Del Rio Torres, N. Chan, S. Ranson, C. Wolke, D.Gulko & Z. Forsman
Department of Land and Natural Resources, Division of Aquatic Resources

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Phenotypic Cell-Based Screening of a High Content Imaging Cell Health Assay using the IN Cell Analyzer 2000
Phenotypic Cell-Based Screening of a High Content Imaging Cell Health Assay using the IN Cell Analyzer 2000
Zaynab Neetoo-Isseljee, Chido Mpamhanga, David Tickle, Debra Taylor and Janet Brownlees
MRC Technology

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A New Approach to the Automated Identification of Metabolites in Multi-Vendor Datasets
A New Approach to the Automated Identification of Metabolites in Multi-Vendor Datasets
Richard Lee,1 Vitaly Lashin,2 Andrey Paramonov,2 Alexandr Sakharov2
1 Advanced Chemistry Development, Inc. (ACD/Labs), 8 King Street East, Toronto, ON, Canada M5C 1B5 2 Advanced Chemistry Development, Ltd. (ACD Ltd.), ul. AkademikaBakuleva6, str.1, Moscow, Russia

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In Silico Drug Degradation Assessment in Early Phase Development
In Silico Drug Degradation Assessment in Early Phase Development
Ali MA, Hemingway R and Ott MA
Lhasa Limited

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Combining a Real-Time In Vitro Cell Viability Assay and RNA Extraction from the Same 3D Spheroids
Combining a Real-Time In Vitro Cell Viability Assay and RNA Extraction from the Same 3D Spheroids
Terry Riss, Sarah Duellman, Brad Hook, Mark Bratz, Samantha Lewis
Promega Corporation

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7c
7c's of learning
Hlulani

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Multiplexed Profiling of the Cellular Stress Response at Multiple Pathway Points
Multiplexed Profiling of the Cellular Stress Response at Multiple Pathway Points
Brad Hook, Chris Eggers, Matthew Robers, Amy Landreman
Promega Corporation

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Evaluation of the 5‐HT<sub>2C</sub> receptor in the human brain in vivo: a [<sup>11</sup>C]Cimbi‐36 PET study
Evaluation of the 5‐HT2C receptor in the human brain in vivo: a [11C]Cimbi‐36 PET study
EA Rabiner1,2, Graham E Searle1, Jan Passchier1, Yvonne Lewis1, Courtney Bishop1, Rexford Newbould1, David J Nutt3, Roger N Gunn1,3, Gitte M Knudsen4, John D Beaver5
1Imanova Limited, 2Kings College, London, 3Imperial College, London, 4University of Copenhagen, 5AbbVie Pharma

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In Vitro Assessment of Drug-Induced Liver Injury (DILI) using a High Content Cellular Imaging System
In Vitro Assessment of Drug-Induced Liver Injury (DILI) using a High Content Cellular Imaging System
Mark Wolfe 1 , Shannon Einhorn 2 , Vanessa Ott 2 , and Haiyan Ma 1
(1) MPI Research Inc., Mattawan, MI (2) Cellular Dynamics International, Madison, WI

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Development of Human iPSC-derived Midbrain Dopaminergic Neurons for Disease Modeling
Development of Human iPSC-derived Midbrain Dopaminergic Neurons for Disease Modeling
S. DeLaura, L. Chase, C. McMahon, J. Ma, N. Meyer, J. Grinager, C. Chavez, B. Swanson, and W.B. Wang
Cellular Dynamics International

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Applications of Human iPS Cell-derived Neurons for Highly Predictive Neurotoxicity Assessment
Applications of Human iPS Cell-derived Neurons for Highly Predictive Neurotoxicity Assessment
G. Salvagiotto, D. Hussey, C. Carlson, A. Thompson, and S. DeLaura
Cellular Dynamics International

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Applications of Human iPS Cell-derived Hepatocytes for Highly Predictive Hepatotoxicity Assessment
Applications of Human iPS Cell-derived Hepatocytes for Highly Predictive Hepatotoxicity Assessment
G. Salvagiotto, C. Carlson, A. Thompson, and D. A. Mann
Cellular dynamics

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Results 21-40 of 138