Horizon Discovery


Dharmacon's expertise in bioinformatics, RNA biology, and synthesis chemistry allowed it to develop a complete line of products for the RNAi researcher, including the first rationally designed siRNA, the siGENOME siRNA collection, targeting all unique genes in the human, mouse, and rat genomes. Further breakthroughs came in chemical modifications for siRNA specificity, and novel molecules for microRNA modulation.

Horizon Discovery Posters
Comparison of cfDNA Reference Material Prepared using Enzymatic Fragmentation or Sonication for the Validation of Liquid Bi
Comparison of cfDNA Reference Material Prepared using Enzymatic Fragmentation or Sonication for the Validation of Liquid Bi
Hannah Child, Aldo Mele, Katarzyna Wilczynska, Julie Wickenden
Horizon Discovery Group

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Reference Standards for the Validation of Myeloid Sequencing Assays
Reference Standards for the Validation of Myeloid Sequencing Assays
M. Wang, H. Child, J. Stombaugh, M. Jakubowski, C. Peck, K. Cook, Y. Cheng, Z. Tu, J. Wickenden
Horizon Discovery Group

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Generation and Validation of Reference Standards for Non-Invasive Prenatal Testing (NIPT)
Generation and Validation of Reference Standards for Non-Invasive Prenatal Testing (NIPT)
A.Mele, E. Surmann, R. Santos, D. Anderson, J. Wickenden, D. Pasupathy, B. Thilaganathan, A. Khalil
Horizon Discovery Group

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Enzymatic fragmentation vs sonication for the production of cfDNA reference standards for liquid biopsy assays
Enzymatic fragmentation vs sonication for the production of cfDNA reference standards for liquid biopsy assays
A. Mele, H. Child, K. Wilczynska, C. Paar, J. Wickenden
Horizon Discovery Group

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Arrayed synthetic CRISPR libraries are a powerful resource for gene knockout or gene activation screening
Arrayed synthetic CRISPR libraries are a powerful resource for gene knockout or gene activation screening
Žaklina Strezoska, Hidevaldo Machado, Matthew Perkett, Eldon Chou, Elena Maksimova, Emily Anderson, Maren Gross, Anja Smith
Dharmacon, part of Horizon Discovery Group

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Potent transcriptional activation with CRISPRa using synthetic crRNA
Potent transcriptional activation with CRISPRa using synthetic crRNA
Žaklina Strezoska, Elena Maksimova, Eldon T. Chou, Maren Mayer Gross, Shawn McClelland, Melissa L. Kelley, and Anja van Brabant Smith
Dharmacon, part of Horizon Discovery Group

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Knockout of microRNAs using the CRISPR-Cas9 system with paired synthetic crRNAs
Knockout of microRNAs using the CRISPR-Cas9 system with paired synthetic crRNAs
Eldon T. Chou, John A. Schiel, Elena Maksimova, Travis Hardcastle, Emily A. Anderson, Annaleen Vermeulen, Anja van Brabant Smith
Dharmacon part of Horizon Discovery Group

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Using machine learning to identify the best CRISPR-Cas9 targets for functional gene knockout
Using machine learning to identify the best CRISPR-Cas9 targets for functional gene knockout
Jesse Stombaugh, Shawn McClelland, Emily M. Anderson, Žaklina Strezoska, Elena Maksimova, Annaleen Vermeulen, Steve Lenger, Tyler Reed, and Anja van Brabant Smith
Dharmacon part of Horizon Discovery Group

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P450 INDUCTION IN CRYOPRESERVED HEPATOCYTES FROM PXR AND CAR NUCLEAR RECEPTOR KNOCK-OUT RATS
P450 INDUCTION IN CRYOPRESERVED HEPATOCYTES FROM PXR AND CAR NUCLEAR RECEPTOR KNOCK-OUT RATS
Kevin P. Forbes1, Kirsten Amaral2 and Albert P. Li2
Horizon Discovery

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A study of transcriptional activation using CRISPRa and synthetic crRNA:tracrRNA
A study of transcriptional activation using CRISPRa and synthetic crRNA:tracrRNA
Maren M. Gross1, Zaklina Stresozka, Elena Maksimova1, Eldon T. Chou1, and Anja van Brabant Smith
Dharmacon part of Horizon Discovery Group

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P450 INDUCTION IN CRYOPRESERVED HEPATOCYTES FROM PXR AND CAR NUCLEAR RECEPTOR KNOCK-OUT RATS
P450 INDUCTION IN CRYOPRESERVED HEPATOCYTES FROM PXR AND CAR NUCLEAR RECEPTOR KNOCK-OUT RATS
Kevin P. Forbes1 , Kirsten Amaral2 and Albert P. Li2
1Horizon Discovery Group Company, Saint Louis, MO 63146 | k.forbes@horizondiscovery.com,

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Chemical modifications of synthetic guide RNA for enhanced RNA stability and reduced cellular toxicity in CRISPR-Cas9 genome editing
Chemical modifications of synthetic guide RNA for enhanced RNA stability and reduced cellular toxicity in CRISPR-Cas9 genome editing
Hidevaldo B. Machado, Megan Basila, Eldon T. Chou, Emily M. Anderson, Melissa L. Kelley, Anja van Brabant Smith
Dharmacon part of Horizon Discovery Group

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Picking the best CRISPR-Cas9 targets for functional gene knockout: a machine learning algorithm based on both specificity and functionality
Picking the best CRISPR-Cas9 targets for functional gene knockout: a machine learning algorithm based on both specificity and functionality
Shawn McClelland, Emily M. Anderson, Žaklina Strezoska, Elena Maksimova, Annaleen Vermeulen, Steve Lenger, Tyler Reed, and Anja van Brabant Smith
Dharmacon part of Horizon Discovery Group

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Applications of chemically modified synthetic guide RNA for CRISPR-Cas9 genome editing
Applications of chemically modified synthetic guide RNA for CRISPR-Cas9 genome editing
Megan Basila, Eldon Chou, Emily Anderson, Melissa L. Kelley, Anja van Brabant Smith Dharmacon, part of GE Healthcare, 2650 Crescent Drive, Lafayette, CO 80026, USA
Dharmacon, part of GE Healthcare

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CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
Michael Delaney, Kaizhang He, Eldon Chou, Amanda Haas, Žaklina Strezoska, Melissa L. Kelley, and Anja van Brabant Smith Dharmacon, part of GE Healthcare, 2650 Crescent Drive, Lafayette, CO 80026, USA
GE Healthcare Dharmacon, Inc.

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Experimental design considerations for homology-directed repair  utilizing a CRISPR-Cas9 system with synthetic crRNA and tracrRNA
Experimental design considerations for homology-directed repair utilizing a CRISPR-Cas9 system with synthetic crRNA and tracrRNA
Hidevaldo B. Machado, John A. Schiel, Maren Mayer-Gross, Eldon T. Chou, Megan Basila, Melissa L. Kelley, Anja van Brabant Smith Dharmacon, part of GE Healthcare, 2650 Crescent Drive, Lafayette, CO 80026, USA
GE Healthcare Dharmacon, Inc.

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A Synthetic CRISPR-Cas9 System for Homology-directed Repair
A Synthetic CRISPR-Cas9 System for Homology-directed Repair
John A. Schiel, Maren M. Gross, Emily M. Anderson*, Eldon T. Chou, Anja van Brabant Smith Dharmacon, part of GE Healthcare, 2650 Crescent Drive, Lafayette, CO 80026, USA
Dharmacon (part of GE Healthcare)

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CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
Kaizhang He, Eldon Chou, Amanda Haas, Žaklina Strezoska, Melissa L. Kelley, and Anja van Brabant Smith Dharmacon, part of GE Healthcare, 2650 Crescent Drive, Lafayette, CO 80026, USA
Dharmacon (part of GE Healthcare)

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Complete alignment identification of CRISPR-Cas9 genomic off-targets using Edit-R CRISPR specificity tool and a comprehensive analysis of positional mismatch tolerance
Complete alignment identification of CRISPR-Cas9 genomic off-targets using Edit-R CRISPR specificity tool and a comprehensive analysis of positional mismatch tolerance
Emily M. Anderson, Shawn McClelland, Amanda Haupt, Eldon T. Chou, John Schiel, Annaleen Vermeulen, Žaklina Strezoska, Hidevaldo Machado, Steve Lenger, Amanda Birmingham, and Anja van Brabant Smith Dharmacon, now part of GE Healthcare, 2650 Crescent Drive, Suite #100, Lafayette, CO 80026, USA
Dharmacon (part of GE Healthcare)

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Knockout of microRNAs using Cas9 nuclease and synthetic crRNA:tracrRNA
Knockout of microRNAs using Cas9 nuclease and synthetic crRNA:tracrRNA
Eldon T. Chou, John A. Schiel, Elena Maksimova, Emily M. Anderson, Melissa L. Kelley, and Anja van Brabant Smith | Dharmacon, part of GE Healthcare, 2650 Crescent Drive, Suite #100, Lafayette, CO 80026, US
Dharmacon (part of GE Healthcare)

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Results 1-20 of 40
Contact Details
Gallery Name: Horizon Discovery
Website: http://www.dharmacon.com
Email: ts.dharmacon@horizondiscovery.com
Telephone:1-800-235-9880 (option 2)